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Related Concept Videos

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

155
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
155

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Related Experiment Video

Updated: Mar 16, 2026

Intravitreous Injection for Establishing Ocular Diseases Model
05:37

Intravitreous Injection for Establishing Ocular Diseases Model

Published on: October 1, 2007

38.1K

Assistive Device for Efficient Intravitreal Injections.

Franziska Ullrich, Stephan Michels, Daniel Lehmann

    Ophthalmic Surgery, Lasers & Imaging Retina
    |August 23, 2016
    PubMed
    Summary
    This summary is machine-generated.

    An automated intravitreal injection system was developed to improve ophthalmic therapy. This device enhances patient safety, reduces procedure time, and lowers costs compared to manual injections.

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    Area of Science:

    • Ophthalmology
    • Medical Device Engineering
    • Robotics

    Background:

    • Intravitreal therapy is crucial for chronic ophthalmic diseases like age-related macular degeneration.
    • Increasing global demand necessitates more efficient, safer, and cost-effective intravitreal injection methods.
    • Manual intravitreal injections present challenges in terms of time, cost, and patient safety.

    Purpose of the Study:

    • To develop and demonstrate an assistive medical device for automated intravitreal injections.
    • To enhance patient safety, procedural efficiency, and cost-effectiveness in ophthalmic therapy.
    • To create a system capable of precise medication delivery through the pars plana.

    Main Methods:

    • Development of a semi-automated intravitreal injection system with human operator coarse positioning.
    • Implementation of automatic fine positioning and injection using the pars plana route.
    • Integration of safety features including continuous eye tracking and iris recognition.

    Main Results:

    • The developed assistive injection system successfully performed intravitreal injections in ex vivo porcine eyes.
    • The system demonstrated potential for increased patient safety and reduced procedure times.
    • The device allows for integrated data storage and documentation, potentially reducing costs.

    Conclusions:

    • An automated intravitreal injection system offers significant advantages over manual procedures.
    • The developed device shows promise for improving the delivery of ophthalmic therapies.
    • Further development could lead to widespread adoption in clinical settings, enhancing patient care.