Related Experiment Video
Updated: Mar 16, 2026
05:49
Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation
Published on: September 29, 2023
1.1K
Logistic ex Vivo Lung Perfusion for Hyperimmunized Patients
Julien De Wolf1, Philippe Puyo1, Pierre Bonnette1
1Department of Thoracic Surgery and Lung Transplantation, Hôpital Foch, Suresnes, France.
The Annals of Thoracic Surgery
|August 24, 2016
Summary
Hyperimmunized patients can undergo lung transplantation using logistic ex vivo lung perfusion while awaiting negative crossmatch results. This innovative approach supports long-term survival in highly sensitized individuals awaiting lung transplants.
Area of Science:
- Immunology
- Cardiology
- Transplantation Medicine
Background:
- Hyperimmunized patients face limited lung transplant access due to donor lung scarcity.
- Human leukocyte antigen sensitization correlates with adverse transplant outcomes, including rejection and reduced survival.
Purpose of the Study:
- To evaluate the efficacy of logistic ex vivo lung perfusion in hyperimmunized patients awaiting lung transplantation.
- To assess the feasibility of lung transplantation in patients requiring negative crossmatch results.
Main Methods:
- Logistic ex vivo lung perfusion was utilized for three hyperimmunized patients awaiting negative prospective crossmatch results.
- Patients proceeded to bilateral lung transplantation after perfusion.
Main Results:
- All three patients survived for at least three years post-bilateral lung transplantation.
- The ex vivo lung perfusion strategy enabled transplantation despite crossmatch waiting times.
Conclusions:
- Logistic ex vivo lung perfusion is a viable strategy for managing hyperimmunized lung transplant candidates.
- This method may improve long-term outcomes for patients with human leukocyte antigen sensitization undergoing lung transplantation.
