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Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of

Magdalena Czeredys1, Filip Maciag1, Axel Methner2

  • 1Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02-109, Warsaw, Poland.

Biochemical and Biophysical Research Communications
|August 25, 2016
PubMed
Summary

Researchers found a compound that may treat Huntington's disease (HD) by restoring calcium homeostasis and stabilizing store-operated calcium entry (SOCE) in neurons. This discovery offers a potential therapeutic avenue for this neurodegenerative disorder.

Keywords:
HuntingtinHuntington's diseaseMedium spiny neuronsStore-operated calcium entryTetrahydrocarbazolesYAC128

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