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Cocaine dependence and thalamic functional connectivity: a multivariate pattern analysis.

Sheng Zhang¹, Sien Hu¹, Rajita Sinha²

¹Department of Psychiatry, Yale University, New Haven, CT 06519, USA; Connecticut Mental Health Center, New Haven, CT 06519, USA.

Neuroimage. Clinical

|August 25, 2016

Summary

This summary is machine-generated.

Cocaine dependence impairs cognitive control, linked to altered thalamic connectivity. This study shows specific thalamic subregions can accurately distinguish cocaine users from controls, highlighting a potential neural marker.

Keywords:

Cocaine Cognitive control Functional connectivity Independent component analysis Multivariate pattern analysis Thalamus

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Area of Science:

Neuroscience
Addiction Research
Cognitive Psychology

Background:

Cocaine dependence is linked to cognitive control deficits.
Chronic cocaine use impacts thalamic activity and connectivity, a key area for cognition.
The specific contribution of thalamic subregions to these cognitive impairments remains unclear.

Purpose of the Study:

To investigate how functional connectivity patterns within the thalamus differentiate individuals with cocaine dependence (CD) from healthy controls (HC).
To identify specific thalamic subregions involved in cognitive dysfunction associated with cocaine dependence.

Main Methods:

Utilized multivariate pattern analysis (MVPA) on fMRI data from a stop-signal task.
Analyzed voxel-wise thalamic connectivity to six task-related networks identified via independent component analysis.
Employed leave-one-out cross-validation for unbiased classification accuracy.

Main Results:

Thalamic connectivity patterns correctly classified 72% of participants as CD or HC (p < 0.001).
Classification accuracy surpassed that of other brain regions of similar size.
Classification-driving thalamic voxels clustered, indicating distinct subregional contributions.

Conclusions:

Thalamic circuit dysfunction is a significant neural marker for cocaine dependence.
Specific thalamic subnuclei connectivities differentiate individuals with cocaine dependence.
Thalamic connectivity alterations may correlate with clinical variables and task performance.