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False Suggestion of Malignant Transformation of Benign Bone Tumor by 18F-FDG PET/CT: A Potential Pitfall
Yu-Ren Chen1, Yu-Cheng Kuo, Cheng-Nan Hsu
1From the *Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung City; †China Medical University, Taichung City; ‡Department of Radiation Oncology, Changhua Show Chwan Memorial Hospital, Changhua County; §Department of Radiation Oncology, China Medical University Hospital, Taichung City; ∥Department of Radiology, China Medical University Hospital, Taichung City; ¶Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung City; and **School of Medicine, China Medical University, Taichung City, Taiwan.
Abstract:
A 68-year-old man underwent serial F-FDG PET/CT scan follow-up for lung cancer. Then 5.5 years after the initial F-FDG PET/CT scan, the presumed benign bone tumor in the left clavicle showed markedly increased FDG uptake during follow-up; in contrast, the Tc-MDP bone scan paradoxically exhibited no apparent interval change since last bone scan 5.5 years earlier. He underwent a CT-guided biopsy, and the pathological diagnosis was benign fibrous histiocytoma. The result was consistent with the lack of progression in Tc-MDP bone scan, whereas the F-FDG PET/CT scan gave a false-positive impression of malignant transformation.
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