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Transition-Metal-Catalyzed Bioorthogonal Cycloaddition Reactions

Maiyun Yang1, Yi Yang1, Peng R Chen2,3

  • 1Synthetic and Functional Biomolecule Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.

Topics in Current Chemistry (Cham)
|August 31, 2016
PubMed
Summary

Bioorthogonal reactions, like copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), enable precise biomolecule labeling in living systems. Ligands reduce copper toxicity, expanding CuAAC applications within cells and on surfaces.

Keywords:
Bioorthogonal reactionCuAAC reactionCycloaddition reactionTransition metalUnnatural amino acids

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