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Related Experiment Video

Updated: Mar 15, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

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Patients, Here Comes More Nanotechnology.

Warren C W Chan1, Buddhisha Udugama1, Pranav Kadhiresan1

  • 1Institute of Biomaterials and Biomedical Engineering, Donnelly Center for Biomolecular Research, Department of Chemistry, Department of Chemical Engineering, Department of Materials Science and Engineering, University of Toronto , 164 College St., Toronto, Ontario M5T 2R5, Canada.

ACS Nano
|August 31, 2016
PubMed
Summary

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Technologists and clinicians differ in reporting nanotechnology diagnostic device performance. Bridging this gap using standardized metrics will accelerate clinical translation of these novel cancer and asthma tests.

Area of Science:

  • Nanotechnology
  • Medical Diagnostics
  • Clinical Translation

Background:

  • Discrepancies exist in how technologists and clinicians report the performance of nanotechnology diagnostic devices.
  • This disparity can hinder the translation of promising nanodiagnostics from academic research to clinical application.

Purpose of the Study:

  • To identify and describe the "metrics" used in evaluating nanotechnology diagnostic devices.
  • To propose strategies for aligning the perspectives of technologists and clinicians.
  • To accelerate the clinical translation of nanotechnology-based diagnostics.

Main Methods:

  • Analysis of reporting differences between technologists and clinicians.
  • Review of evaluation metrics for nanotechnology diagnostic devices.

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  • Case studies using silicon nanowire and surface-enhanced Raman spectroscopy-breath diagnostic tests for cancer and asthma.

    • Main Results:

    • Identified key differences in performance reporting between scientific and clinical communities.
    • Highlighted the importance of clinical parameters in evaluating emerging nanodiagnostics.
    • Demonstrated the application of these principles in recent studies.

    Conclusions:

    • Standardizing performance metrics is crucial for effective communication and collaboration.
    • Adoption of shared evaluation strategies will expedite the clinical integration of nanotechnology diagnostics.
    • Bridging the technologist-clinician gap is essential for advancing nanomedicine.