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Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals

Saravana K Ramasamy1,2, Anjali P Kusumbe1,2, Tomer Itkin3

  • 1Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, D-48169 Münster, Germany;

Annual Review of Cell and Developmental Biology
|August 31, 2016
PubMed

In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.

Keywords:
angiocrine factorsbone angiogenesishematopoietic stem cellsvascular niche

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