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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
35.7K
Targeting IL-17 in autoimmunity and inflammation.
Byung-Seok Kim1,2, Young-Jun Park1, Yeonseok Chung3,4
1Laboratory of Immune Regulation, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
Archives of Pharmacal Research
|September 1, 2016
Summary
Helper T cells include Th1 and Th2 subsets. A third subset, IL-17-producing T cells, also drives autoimmune inflammation and offers therapeutic targets for immune disorders.
Area of Science:
- Immunology
- Cell Biology
Background:
- Discovery of Th1 and Th2 cells advanced understanding of inflammatory diseases.
- Autoimmune diseases in mice lacking Th1/Th2 responses suggested other T cell subsets exist.
Purpose of the Study:
- To review the biology of Interleukin-17 (IL-17).
- To discuss the therapeutic potential of targeting IL-17 for immune disorders.
Main Methods:
- Literature review of studies on T cell subsets and IL-17.
- Analysis of research identifying IL-17-producing cells and their role in inflammation.
Main Results:
- Identification of IL-17-producing RORγt+CD4+ T cells as a distinct helper T cell subset.
- Involvement of innate immune cells (γδ T cells, NKT cells, innate lymphoid cells) in producing IL-17 and contributing to inflammation.
Conclusions:
- IL-17-producing T cells are crucial mediators of autoimmune tissue inflammation.
- Targeting IL-17 presents a promising therapeutic strategy for various immune disorders.
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