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Neostriatal Neuronal Activity Correlates Better with Movement Kinematics under Certain Rewards.

Ioan Opris¹, Mikhail A Lebedev², Randall J Nelson³

¹Miami Project, University of Florida Miami, FL, USA.

Frontiers in Neuroscience

|September 1, 2016

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Neostriatal neuron activity links more strongly to wrist movement kinematics when rewards are certain, movements are flexions, and cues are visual. This finding aids neuroprosthesis development.

Area of Science:

Neuroscience
Motor Control
Computational Neuroscience

Background:

The neostriatum plays a crucial role in motor control and learning.
Understanding neural activity during movement is key to developing advanced neuroprosthetics.

Purpose of the Study:

To investigate the relationship between neostriatal neuronal activity and wrist movement kinematics.
To determine how reward contingency, sensory cues, and movement direction influence this relationship.

Main Methods:

Single-unit recordings of neostriatal neurons in monkeys performing cued wrist movements.
Analysis using regression models to correlate neuronal activity with kinematic variables (position, velocity, acceleration).
Comparison of correlation coefficients (CoD) and timing (ToC) across different experimental conditions.

Keywords:

basal ganglia hand movement motivation movement preparation multilinear regression neostriatum neuronal activity reward uncertainty

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Main Results:

Neostriatal neuronal activity showed a stronger correlation with movement kinematics during trials with certain rewards compared to uncertain rewards.
The correlation was greater during flexion movements than extension movements.
Visual cues resulted in a stronger correlation than vibratory cues.

Conclusions:

Reward predictability enhances the linkage between neostriatal pre-movement activity and movement vigor.
Sensory modality and movement direction also influence this neural-kinematic relationship.
Findings offer insights for designing upper-limb neuroprosthetic devices.