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Updated: Mar 15, 2026

Investigating Receptor-ligand Systems of the Cellulosome with AFM-based Single-molecule Force Spectroscopy
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Investigating Receptor-ligand Systems of the Cellulosome with AFM-based Single-molecule Force Spectroscopy

Published on: December 20, 2013

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Single versus dual-binding conformations in cellulosomal cohesin-dockerin complexes.

Michael A Nash1, Steven P Smith2, Carlos Mga Fontes3

  • 1Lehrstuhl für Angewandte Physik and Center for Nanoscience, Ludwig-Maximilians-Universität, 80799 Munich, Germany; Department of Chemistry, University of Basel, 4056 Basel, Switzerland; Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH-Zürich), 4058 Basel, Switzerland.

Current Opinion in Structural Biology
|September 1, 2016
PubMed
Summary

Cohesin-dockerin complexes exhibit remarkable biochemical affinity and mechanostability, crucial for cellulosome assembly. Their unique dual-binding mode challenges traditional receptor-ligand interaction models.

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