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Experimental Forelimb Allotransplantation in Canine Model.
Sa-Hyeok Hong1, Seok-Chan Eun1
1Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul 463-706, Republic of Korea.
Biomed Research International
|September 7, 2016
Summary
This study details canine forelimb allotransplantation, a crucial preclinical model for upper limb reconstructive transplantation. The research outlines surgical techniques and demonstrates the model
Area of Science:
- Veterinary Surgery
- Transplantation Immunology
- Reconstructive Surgery
Background:
- Reconstructive transplantation is an emerging option for upper limb amputees.
- Preclinical research in rodent and swine models exists, but canine models are underrepresented.
- Plastic surgeons require updated skills for advanced reconstructive procedures.
Purpose of the Study:
- To provide an overview of surgical techniques for canine forelimb allotransplantation.
- To establish a canine model for preclinical research and surgical training.
- To prepare for potential clinical applications of forelimb transplantation.
Main Methods:
- 18 canine forelimb allotransplantation surgeries were performed.
- Surgical steps included bone fixation, muscle/tendon repair, nerve coaptation, and vascular anastomosis.
- Postoperative immunosuppression with FK-506 (tacrolimus) was administered for 7 days.
Main Results:
- The mean surgical time was 5 hours and 30 minutes.
- Most allografts exhibited excellent viability without early vascular complications.
- The canine model proved suitable for transplantation training and research.
Conclusions:
- Canine forelimb allotransplantation is a viable preclinical model.
- The described surgical approach is effective for establishing the model.
- This model can facilitate further research and training for reconstructive transplantation.
