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Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography
Christian Böni1, Jennifer E Thorne2, Richard F Spaide3
1Ocular Inflammatory Disease Center UCLA Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Investigative Ophthalmology & Visual Science
|September 7, 2016
Summary
Enhanced depth imaging optical coherence tomography (EDI-OCT) reveals common choroidal abnormalities in birdshot chorioretinitis (BSCR). These lesions correlate with inflammation and disease activity, offering insights into BSCR mechanisms and treatment response.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Birdshot chorioretinitis (BSCR) is a posterior uveitis affecting the choroid.
- Understanding choroidal changes is crucial for managing BSCR.
Purpose of the Study:
- To characterize choroidal findings in BSCR using enhanced depth imaging optical coherence tomography (EDI-OCT).
- To investigate the association between these choroidal findings and patient demographics, clinical features, and treatments.
Main Methods:
- A multicenter, cross-sectional study involving 172 eyes from 86 BSCR patients.
- Standardized clinical evaluation and EDI-OCT imaging (macular and peripapillary scans).
- Logistic regression analysis to compare choroidal findings with clinical data.
Main Results:
- Choroidal lesions were identified in 63.6% of eyes.
- Lesions correlated with longer disease duration, increased vitreous haze, macular edema, and thicker choroids.
- Immunomodulatory therapy was linked to a lower risk of abnormal choroidal thickness.
Conclusions:
- EDI-OCT frequently detects choroidal abnormalities in BSCR, particularly in macular and peripapillary areas.
- These lesions likely represent active disease foci and correlate with inflammatory signs.
- EDI-OCT shows potential for monitoring BSCR disease activity and treatment efficacy.
