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Related Concept Videos

Masking and Demasking Agents01:19

Masking and Demasking Agents

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EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
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Sodium Deoxycholate for Submental Contouring.

S Humphrey1, K Beleznay1, J D A Beleznay2

  • 1Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.

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|September 8, 2016
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Summary

Submental fat, or fat under the chin, can be reduced using a new injectable treatment. This non-surgical option, ATX-101 (deoxycholic acid), offers a safe and effective alternative to cosmetic surgery for improving facial aesthetics.

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Area of Science:

  • Aesthetic medicine
  • Dermatology
  • Injectable treatments

Background:

  • Submental fat negatively impacts facial aesthetics and patient satisfaction.
  • Current treatments like liposuction have limitations, including surgical risks and recovery time.
  • Non-invasive options for submental fat reduction with strong evidence are limited.

Purpose of the Study:

  • To evaluate the safety and efficacy of ATX-101 for submental fat reduction.
  • To provide an evidence-based, non-surgical treatment option for aesthetic concerns related to submental fat.

Main Methods:

  • ATX-101, a synthetic deoxycholic acid formulation, was investigated.
  • A comprehensive clinical development program was conducted.
  • Regulatory approval was sought and granted based on established safety and efficacy.

Main Results:

  • The injectable formulation ATX-101 demonstrated established safety and efficacy.
  • Clinical trials supported its use for reducing submental fat.
  • Regulatory authorities in Canada (Belkyra™) and the US (Kybella®) approved the treatment.

Conclusions:

  • ATX-101 is an approved, effective, and safe non-surgical treatment for submental fat.
  • It provides a valuable alternative to surgical interventions for improving the chin and jawline profile.
  • The injectable offers a new option for patients seeking to address aesthetic concerns related to submental fat.