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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives
Torsten Busch1, Gerald Dräger, Eike Kunst
1Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1b, 30167 Hannover, Germany. andreas.kirschning@oci.uni-hannover.de.
Organic & Biomolecular Chemistry
|September 9, 2016
Abstract:
The synthesis of the diterpene (+)-tonantzitlolone A and a series of derivatives is reported. The study includes the determination of their antiproliferative activities against selected cancer cell lines.

