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Furfuryl methacrylate plasma polymers for biomedical applications
Hanieh Safizadeh Shirazi1, Nicholas Rogers1, Andrew Michelmore2
1Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, South Australia 5095, Australia and Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Lakes, South Australia 5095, Australia.
Furfuryl methacrylate (FMA) plasma polymer coatings were optimized for biomedical use. Controlling plasma parameters reduced particle aggregates, improving uniformity and smoothness for better cell culture applications.
Area of Science:
- Materials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Furfuryl methacrylate (FMA) is a versatile precursor for advanced polymer synthesis.
- Biomedical applications require precisely controlled polymer surface properties.
Purpose of the Study:
- To investigate the effect of plasma polymerization parameters on FMA coating properties.
- To assess the impact of surface characteristics on human fibroblast behavior.
Main Methods:
- Plasma polymerization of FMA with varied power, time, and flow rates.
- Surface characterization using AFM, SEM, XPS, and ToF-SIMS.
- Culturing primary human fibroblasts on fabricated surfaces.
Main Results:
- AFM and SEM revealed particle aggregates during early coating growth.
- XPS showed no significant chemical differences across varied conditions.
- ToF-SIMS detected variations in furan-related species (C5H5O, C10H9O2).
- Optimized parameters yielded smooth, chemically uniform coatings with fewer aggregates.
Conclusions:
- Plasma polymerization of FMA can be controlled to produce uniform, smooth coatings.
- Particle aggregates on FMA surfaces inhibit fibroblast attachment and proliferation.
- Optimized FMA coatings show potential for biomedical and cell therapy applications.
