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Related Experiment Video

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Diffusion Imaging in the Rat Cervical Spinal Cord
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New insights about time-varying diffusivity and its estimation from diffusion MRI.

Lipeng Ning1, Kawin Setsompop2, Carl-Fredrik Westin3

  • 1Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Magnetic Resonance in Medicine
|September 10, 2016
PubMed
Summary
This summary is machine-generated.

This study introduces new methods to measure time-dependent diffusivity using diffusion MRI. These techniques reveal insights into microscopic tissue structure and brain data.

Keywords:
autocorrelation functiondiffusion MRImean-squared displacementoscillating gradient spin-echosingle-diffusion encodingtime-varying diffusivity

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Area of Science:

  • Magnetic Resonance Imaging
  • Biophysics
  • Neuroscience

Background:

  • Understanding microscopic tissue structure relies on estimating time-dependent diffusivity.
  • Diffusion MRI signal characterization is key to this estimation.

Purpose of the Study:

  • Extend Stepišnik's theory for time-dependent diffusivity measurement.
  • Derive novel expressions for the diffusion MRI signal.
  • Propose and test models for time-varying diffusivity.

Main Methods:

  • Gaussian phase approximation
  • Derivation of signal expressions based on mean-squared displacement, instantaneous diffusivity, and velocity autocorrelation function.
  • Application to single diffusion encoding and oscillating gradient spin-echo sequences.
  • Monte-Carlo simulations and in vivo human brain data analysis.

Main Results:

  • Novel expressions for diffusion MRI signal were derived.
  • Proposed models successfully distinguished synthetic structures in simulations.
  • Strong statistical evidence for time-varying diffusivity was found in human brain data.

Conclusions:

  • The developed theory offers new insights into time-varying diffusivity using various gradient sequences.
  • The proposed models are applicable for studying time-varying diffusivity in human brain diffusion MRI data.