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Disappearance of Idiopathic Outflow Tract Premature Ventricular Contractions After Catheter Ablation of Overt
Tamas Szili Torok1, Lennart J DE Vries1, Emin E Özcan2
1Department of Cardiology, Electrophysiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Background:
Multiple mechanisms have been proposed for idiopathic premature ventricular contractions (PVCs) originating from the outflow tracts (OTs). Recent observations such as the coexistence of these arrhythmias with atrioventricular nodal reentrant tachycardias and the association between discrete prepotentials and successful ablation sites of ventricular arrhythmias (VAs) from the OTs suggest a common link.
Objective:
In this case series we draw attention to a unique association between accessory pathways (APs) and idiopathic PVCs from the OTs, disappearing after AP ablation.
Methods:
We identified 6 cases in collaboration with several international electrophysiology centers, which presented with pre-excitation in association with OT, and in 1 case inflow tract (IT), PVCs on 12-lead surface ECG.
Results:
Six cases displayed pre-excitation and PVCs, in 5 cases originating from the right ventricular outflow tract (RVOT) and in 1 case from the right ventricular inflow tract (RVIT). In all patients, PVCs were monomorphic and had fixed coupling intervals, in 3 cases presenting in bigeminy. Catheter ablation of the AP led to the simultaneous disappearance of PVCs in 5 of 6 cases. The sites of ablation were remote from the OTs in all these cases. In most cases, the occurrence of OT PVCs was closely associated with the presence of pre-excitation.
Conclusion:
The coexistence of pre-excitation and PVCs from the OTs and the fact that in 5 of 6 cases PVCs disappeared after AP ablation suggests a common mechanism for arrhythmia genesis.
Insights
Idiopathic premature ventricular contractions (PVCs) from the outflow tracts may be linked to accessory pathways (APs). Ablating APs often resolves these PVCs, suggesting a shared origin for both conditions.
Area of Science:
- Cardiology
- Electrophysiology
- Cardiac Arrhythmias
Background:
- Idiopathic premature ventricular contractions (PVCs) originating from the outflow tracts (OTs) have multiple proposed mechanisms.
- Coexistence with atrioventricular nodal reentrant tachycardias and association with successful ablation sites suggest a common link.
Purpose of the Study:
- To highlight a unique association between accessory pathways (APs) and idiopathic PVCs originating from the OTs.
- To investigate the effect of AP ablation on these PVCs.
Main Methods:
- A case series of 6 patients with pre-excitation and outflow tract (OT) PVCs identified.
- Analysis of 12-lead surface ECGs and outcomes after accessory pathway ablation.
Main Results:
- Six cases showed pre-excitation and PVCs, mostly from the right ventricular outflow tract (RVOT).
- Catheter ablation of the accessory pathway resolved PVCs in 5 out of 6 cases, with ablation sites remote from the OTs.
- PVC occurrence was closely associated with the presence of pre-excitation.
Conclusions:
- The coexistence of pre-excitation and OT PVCs suggests a common mechanism for their genesis.
- Successful AP ablation leading to PVC resolution supports a shared pathway in arrhythmia development.
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