[Effect of gelatin solution on parameters of tablets containing well-compressible active principles]

Theobromine tablets have been prepared by wet granulation using gelatin solutions of various concentrations. It has been established that film formed from 2 per cent gelatin solution does not assure sufficient binding force. Lamella forming tendency could be observed on tablets. Furthermore, it has been ascertained that tablets proper in respects of both physical parameters and active principle release can be prepared with 5 per cent gelatin solution. It seems to be unnecessary to use 10 per cent gelatin solution. Behaviour of gelatin solutions at compression of starch and their role in active principle release have been discussed. Attention has been drawn to loss of biological value because of the "aging" of the gelatin film.