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Skin absorption through atopic dermatitis skin: a systematic review
A-S Halling-Overgaard1,2, S Kezic3, I Jakasa4
1Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, DK-2900, Hellerup, Denmark.
The British Journal of Dermatology
|September 18, 2016
Summary
Patients with atopic dermatitis (AD) show significantly higher skin absorption of topical substances. This increased absorption highlights potential risks of contact allergy and systemic exposure to chemicals in AD patients.
Area of Science:
- Dermatology
- Pharmacokinetics
- Toxicology
Background:
- Atopic dermatitis (AD) is characterized by impaired skin barrier function.
- AD patients frequently use emollients and topical anti-inflammatory drugs.
- This usage increases risk for contact allergy and systemic chemical exposure.
Purpose of the Study:
- To systematically review studies on skin absorption in AD patients.
- To compare skin absorption in AD patients versus healthy controls and animal models.
- To assess systemic exposure risks to chemicals in topical preparations for AD.
Main Methods:
- Systematic literature search for studies on skin absorption of penetrants and drugs.
- Inclusion of human studies (model penetrants, AD drugs) and animal studies.
- Analysis of dermatopharmacokinetic data in patients with AD.
Main Results:
- Identified 40 relevant articles (11 model penetrants, 26 AD drugs, 3 animal studies).
- Patients with AD exhibited nearly twofold increased skin absorption compared to healthy controls.
- Evidence suggests higher systemic exposure to chemicals in AD patients.
Conclusions:
- Atopic dermatitis significantly enhances skin absorption of topical agents.
- Further epidemiological and dermatopharmacokinetic studies are needed.
- Quantifying systemic chemical exposure in AD patients requires more research.
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