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Current advances in electrospun gelatin-based scaffolds for tissue engineering applications
Ana A Aldana1, Gustavo A Abraham1
1Instituto de Investigaciones en Ciencia y Tecnología de Materiales, INTEMA (UNMdP-CONICET), Av. Juan B. Justo 4302, B7608FDQ Mar del Plata, Argentina.
International Journal of Pharmaceutics
|September 20, 2016
Summary
Electrospun gelatin scaffolds offer versatile biomimetic platforms for tissue engineering. These highly-porous nanofiber scaffolds show promise for bone, cartilage, skin, and vascular applications.
Area of Science:
- Biomedical Engineering
- Materials Science
Background:
- Biomimetic scaffolds are crucial for tissue engineering.
- Electrospun nanofibers provide versatile platforms for biomedical applications like wound dressings and drug delivery.
- Micro/nanoscale fibrous structures are of significant interest in healthcare.
Purpose of the Study:
- To review and discuss electrospun gelatin-based scaffolds for diverse tissue engineering applications.
- To highlight the attractive properties of gelatin blends for scaffolding.
- To present current advances and challenges in the field.
Main Methods:
- Mini-review of existing literature on electrospun gelatin scaffolds.
- Discussion of gelatin blends with natural or synthetic polymers.
- Analysis of physicochemical, biomechanical, and biocompatibility properties.
Main Results:
- Electrospun gelatin scaffolds are suitable for bone, cartilage, skin, nerve, ocular, and vascular tissue engineering.
- Gelatin blends demonstrate desirable properties for scaffold development.
- The review consolidates current progress and identifies research gaps.
Conclusions:
- Electrospun gelatin-based scaffolds are promising for various tissue engineering applications.
- The versatility and tunable properties of gelatin blends support their use in regenerative medicine.
- Further research is needed to address existing challenges and optimize scaffold performance.
