Related Experiment Video
Updated: Mar 14, 2026
13:47
Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
Published on: May 19, 2020
3.9K
[Is the simplification of the immunization schedule applied? Review 2 years after its implementation]
J Gaudelus1, F Denis2, R Cohen3
1Service de pédiatrie, hôpital Jean-Verdier, 93140 Bondy, France; Université Paris-XIII, 93017 Bobigny, France.
Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|September 21, 2016
Summary
The 2013 infant immunization schedule simplification was rapidly adopted, improving vaccine coverage for DTPa-Hib, MMR, and meningitis C vaccines. However, further efforts are needed to achieve all public health vaccination coverage objectives.
Area of Science:
- Pediatrics
- Public Health
- Immunology
Background:
- Vaccine coverage (VC) evaluations are crucial for assessing vaccination policy effectiveness.
- The 2013 immunization schedule in France aimed to simplify infant vaccination protocols.
Purpose of the Study:
- To evaluate vaccine coverage in infants following the implementation of the revised 2013 immunization schedule.
- To assess the impact of schedule simplification on adherence to vaccination recommendations.
Main Methods:
- An online study surveyed a representative sample of mothers regarding their child's vaccination records.
- Data was collected in 2014 to compare with previous vaccination coverage rates from 2012.
Main Results:
- Rapid adoption of the simplified schedule, with a significant decrease in DTPa doses at 3 months and earlier MMR and hepatitis B boosters.
- Increased vaccine coverage for meningitis C in children aged 15-23 months (66% in 2014 vs. 44% in 2012).
- Higher rates of two-dose MMR vaccination by 18-20 months (60% in 2014 vs. 41% in 2012).
Conclusions:
- The simplified infant immunization schedule was quickly adopted by healthcare professionals.
- While the simplification improved adherence, it was not sufficient to meet all defined public health vaccination coverage goals.
Related Concept Videos
01:51Vaccinations
53.2K
Overview
53.2K
01:29Drug Dosing: Infants and Children
677
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
677
01:23Immunological Memory
17.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.7K
01:22Development of Immunocompetence
1.1K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
01:21Drug Accumulation During Multiple Dosing: Repetitive IV Injections
367
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
367
01:19Dosage Interval and Administration Route: Determination Methods
393
A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to...
393