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Genetic Vulnerability as a Distal Risk Factor for Suicidal Behaviour: Historical Perspective and Current Knowledge
Karl Andriessen1, Alja Videtic-Paska2
1University of New South Wales, School of Psychiatry, Black Dog Institute, Hospital Rd, Randwick, NSW 2031, Australia.
Zdravstveno Varstvo
|September 21, 2016
Summary
Genetic factors contribute significantly to suicidal behavior, potentially explaining up to half of its occurrence. This genetic vulnerability is distinct from that of psychiatric disorders and has ethical implications.
Area of Science:
- Psychiatry
- Genetics
- Behavioral Science
Background:
- Suicide is a complex issue with evidence suggesting a genetic component.
- Family history of suicide indicates a potential inherited predisposition to suicidal behavior.
Purpose of the Study:
- To review the current understanding of genetic vulnerability to suicidal behavior.
- To differentiate this vulnerability from genetic predispositions to psychiatric disorders.
- To incorporate findings from clinical, population-based, and molecular genetics studies.
Main Methods:
- Comprehensive literature search of peer-reviewed articles and reviews.
- Databases searched include PubMed/Medline and PsycINFO.
- Focus on English-language professional literature.
Main Results:
- The literature confirms a genetic vulnerability to suicidal behavior.
- Genetic influences may account for up to 50% of the variance in suicide occurrence.
- Challenges exist in comparing results across individual studies.
Conclusions:
- Genetic vulnerability acts as a distal risk factor for suicide.
- Understanding this genetic link aids in comprehending suicide in vulnerable populations.
- The ethical implications of genetic vulnerability to suicide are significant.
Keywords:
ethical considerationsfamiliesgeneticsoffspringsprobandsreviewsuicidal behavioursuicidevulnerabilityMore Related Videos
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