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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

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Portable Cytometry Using Microscale Electronic Sensing.

Sam Emaminejad¹, Kee-Hyun Paik², Vincent Tabard-Cossa³

¹Electrical Engineering and Computer Science Department, University of California Berkeley, Berkeley, CA, USA; School of Medicine, Stanford University, Stanford, CA, USA.

Sensors and Actuators. B, Chemical

|September 21, 2016

Summary

This summary is machine-generated.

This study introduces three micro-impedance sensing methods for electronic cell and bead counting. These novel architectures offer improved signal processing and reduced costs for impedance cytometry applications.

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Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

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Area of Science:

Biomedical Engineering
Microfluidics
Biosensing

Background:

Accurate electronic counting of cells and beads is crucial for various biological and medical applications.
Existing impedance cytometry methods face challenges in signal-to-noise ratio and consumable costs.

Purpose of the Study:

To present and validate three novel micro-impedance sensing architectures for electronic particle counting.
To explore different sensing strategies including open-circuit, differential, and contactless measurements.

Main Methods:

Fabrication of a funnel-shaped microchannel in PDMS on a gold electrode-patterned glass substrate for open-circuit sensing.
Implementation of a three-electrode differential measurement system.
Development of a contactless sensing architecture to reduce consumable costs.
Integration of amplification circuitry on a custom printed circuit board.

Main Results:

Demonstrated proof of concept for all three micro-impedance sensing architectures.
Successfully measured signals from micron-sized beads passing through the micro-pores.
Validated the potential for electronic counting of cells and beads.

Conclusions:

The presented micro-impedance sensing architectures offer viable solutions for electronic cell and bead counting.
The differential and contactless methods show promise for enhanced signal processing and cost reduction in impedance cytometry.