Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

449
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
449
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.2K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.2K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.7K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.7K
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

563
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
563
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

506
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
506
Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

977
Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
977

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disentangling Centrality Bias and Final-State Effects in the Production of High-p_{T} Neutral Pions Using Direct Photon in d+Au Collisions at sqrt[s_{NN}]=200  GeV.

Physical review letters·2025
Same author

Dapsone Induced Methaemoglobinaemia A reminder the iatrogenic causes of cyanosis.

Irish medical journal·2023
Same author

Measurement of Direct-Photon Cross Section and Double-Helicity Asymmetry at sqrt[s]=510  GeV in p[over →]+p[over →] Collisions.

Physical review letters·2023
Same author

Is perinatal substance abuse falling through the cracks?

Irish journal of psychological medicine·2023
Same author

Examining the impact of premature birth on parental mental health and family functioning in the years following hospital discharge: A review.

Journal of neonatal-perinatal medicine·2023
Same author

Probing Gluon Spin-Momentum Correlations in Transversely Polarized Protons through Midrapidity Isolated Direct Photons in p^{↑}+p Collisions at sqrt[s]=200  GeV.

Physical review letters·2021

Related Experiment Video

Updated: Mar 14, 2026

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
12:27

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

17.0K

Anticoagulation management during cross-clamping and bypass.

H Lander1, M Zammert1, D FitzGerald1

  • 1Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.

Best Practice & Research. Clinical Anaesthesiology
|September 22, 2016
PubMed
Summary

Anticoagulation management is crucial for cardiopulmonary bypass (CPB) and aortic occlusion surgeries. Unfractionated heparin is the primary anticoagulant, with activated clotting time monitoring essential for safe procedures.

Keywords:
activated clotting timeanticoagulationcardiopulmonary bypassheparinheparin concentration assay

More Related Videos

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

4.2K
Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
12:00

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

Published on: November 24, 2014

15.9K

Related Experiment Videos

Last Updated: Mar 14, 2026

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
12:27

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

17.0K
Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

4.2K
Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
12:00

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

Published on: November 24, 2014

15.9K

Area of Science:

  • Cardiovascular Surgery
  • Hematology
  • Anesthesiology

Background:

  • Anticoagulation is essential for cardiopulmonary bypass (CPB) and surgeries involving aortic occlusion.
  • Coagulation and fibrinolysis are activated during CPB, necessitating careful management.
  • Thrombosis and excessive bleeding are risks associated with inadequate anticoagulation.

Purpose of the Study:

  • To review the current strategies for anticoagulation management during CPB and aortic cross-clamp procedures.
  • To highlight the importance of appropriate anticoagulation dosing, monitoring, and maintenance.
  • To discuss the role of unfractionated heparin and its monitoring methods.

Main Methods:

  • Review of existing literature on anticoagulation during CPB and aortic occlusion.
  • Analysis of current monitoring techniques, including activated clotting time (ACT) and heparin concentration.
  • Discussion of unfractionated heparin as the primary anticoagulant in these settings.

Main Results:

  • Unfractionated heparin is the predominant anticoagulant used in CPB and aortic occlusion surgeries.
  • Activated clotting time (ACT) and heparin concentration are key monitoring parameters.
  • Effective anticoagulation prevents circuit thrombosis and minimizes hemostatic system activation.

Conclusions:

  • Optimal anticoagulation is vital for the success of CPB and aortic occlusion surgeries.
  • Current management relies heavily on unfractionated heparin and ACT monitoring.
  • Further research into novel anticoagulants and advanced monitoring may improve patient outcomes.