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Published on: February 10, 2023
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Guidance on liquid-based cytology system conversion training: a secondary publication
1Pathology Department, Monklands Hospital, Airdrie, UK. allan.wilson@lanarkshire.scot.nhs.uk.
Summary
Transitioning to HPV primary screening requires careful training for liquid-based cytology (LBC). Proper training ensures accuracy in cervical sample analysis, crucial for effective screening programs.
Area of Science:
- Cytopathology
- Public Health Screening
Background:
- National cervical screening programs are shifting towards Human Papillomavirus (HPV) primary screening.
- HPV testing necessitates cervical samples in liquid-based cytology (LBC) media for triage cytology.
Purpose of the Study:
- To highlight the resource requirements and potential pitfalls in converting from conventional smears to LBC.
- To emphasize the necessity of structured training and performance monitoring for laboratory staff during LBC technology adoption.
Main Methods:
- Review of conversion processes in UK laboratories transitioning between LBC technologies (Thinprep and Surepath).
- Emphasis on structured conversion courses with measurable outcomes for all relevant staff, including screeners and cytopathologists.
Main Results:
- Conversion training is estimated to require approximately 39 hours.
- A minimum performance standard of 95% high-grade sensitivity and 70% specificity must be achieved post-training.
Conclusions:
- Structured training and performance monitoring are critical for successful implementation of LBC in cervical screening.
- Ensuring staff competence through comprehensive training is paramount before adopting new LBC technologies for HPV primary screening.

