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A 3D Organotypic Melanoma Spheroid Skin Model
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"Malignant Cutaneous Ulcer".

Deepak Sundriyal1, Sumedha Kotwal2

  • 1Department of Medical oncology, Dharamshila Hospital & Research Centre, Vasundhara Enclave, New Delhi 110096 India ; Department of Pathology, Dharamshila Hospital & Research Centre, Vasundhara Enclave, New Delhi 110096 India.

Indian Journal of Surgical Oncology
|September 22, 2016
PubMed
Summary
This summary is machine-generated.

Renal cell carcinoma (RCC), an aggressive cancer, can spread through blood vessels, sometimes appearing as skin lesions late in the disease. Awareness of these cutaneous signs is crucial for diagnosing unknown primary cancers.

Keywords:
Cutaneous ulcerPolycystic kidneyRenal cell carcinoma

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Renal cell carcinoma (RCC) is a highly aggressive cancer.
  • Its rich vascularity facilitates early hematogenous metastasis.
  • Cutaneous manifestations are typically late signs of advanced RCC.

Purpose of the Study:

  • To highlight the significance of skin lesions as a potential indicator of renal cell carcinoma (RCC).
  • To increase clinician awareness regarding the cutaneous presentation of RCC.
  • To emphasize the importance of considering RCC in patients with unexplained skin lesions and a primary unknown.

Main Methods:

  • Literature review of case reports and clinical studies on RCC with cutaneous metastasis.
  • Analysis of clinical features and diagnostic pathways for patients presenting with skin lesions and subsequent RCC diagnosis.

Main Results:

  • Skin lesions can be an uncommon but significant late manifestation of renal cell carcinoma.
  • Metastatic RCC to the skin can present with various morphologies, mimicking other dermatoses.
  • Early recognition of cutaneous signs may aid in the diagnosis of occult RCC.

Conclusions:

  • Clinicians must maintain a high index of suspicion for underlying malignancy, including RCC, in patients with new-onset or unexplained skin lesions.
  • Cutaneous metastases of RCC, though a late sign, warrant thorough investigation for primary tumor detection.
  • Integrating dermatological findings into the diagnostic workup can improve the detection rates of advanced renal cell carcinoma.