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Updated: Mar 14, 2026
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
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[What is new in basal cell carcinoma?]
M Heppt1, T von Braunmühl1, C Berking2
1Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München (LMU), Frauenlobstr. 9-11, 80337, München, Deutschland.
Summary
Basal cell carcinoma (BCC) treatment advances include improved diagnosis with imaging and new systemic therapies. Targeted therapies offer improved outcomes for advanced BCC but require careful management of side effects.
Area of Science:
- Dermatology
- Oncology
- Medical Imaging
Background:
- Basal cell carcinoma (BCC) is the most common skin cancer in fair-skinned individuals.
- While rare, metastatic BCC can be fatal due to aggressive growth.
- Current understanding and management strategies are continually evolving.
Purpose of the Study:
- To provide a comprehensive update on the diagnosis, treatment, and prevention of Basal Cell Carcinoma (BCC).
- To summarize recent advancements and current recommendations for BCC management.
Main Methods:
- Review of current literature and German guidelines on skin cancer treatment and prevention.
- Synthesis of pertinent developments in BCC diagnosis and therapy.
Main Results:
- Optical coherence tomography and reflectance confocal microscopy enhance BCC diagnosis.
- Mohs micrographic surgery is the gold standard for high-risk and facial BCC.
- Systemic sonic hedgehog (SHH) pathway inhibitors (vismodegib, sonidegib) show efficacy in advanced/metastatic BCC, with common side effects including muscle cramps and fatigue.
- Oral nicotinamide (vitamin B3) demonstrated a 20% reduction in new BCC occurrence in a phase III trial.
Conclusions:
- Targeted SHH inhibitor therapy has improved prognosis for advanced and metastatic BCC.
- Significant adverse events are associated with SHH inhibitor treatment.
- Further research into prevention strategies, such as vitamin B3, is warranted.
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