[Research progress in relationship between fractional exhaled nitric oxide and asthma in children]

Area of Science:

• Pediatric Pulmonology
• Allergy and Immunology
• Respiratory Medicine

Background:

• Bronchial asthma in children presents as airway hyperresponsiveness and chronic inflammation, often with reversible airflow obstruction.
• Traditional lung function tests are challenging for preschoolers due to cooperation issues and do not assess airway inflammation severity.
• Fractional exhaled nitric oxide (FeNO) is an emerging noninvasive biomarker for airway inflammation.

Purpose of the Study:

• To review the source and reference values of FeNO in laboratory testing.
• To explore the application progress of FeNO in diagnosing, predicting, and treating pediatric asthma.
• To highlight FeNO as a valuable tool for managing childhood asthma.

Main Methods:

• Literature review focusing on Fractional exhaled nitric oxide (FeNO) in pediatric asthma.
• Analysis of FeNO's utility across various age groups in children.
• Comparison of FeNO with traditional lung function tests.

Main Results:

• FeNO is a simple, objective, and noninvasive indicator of airway inflammation.
• FeNO testing is increasingly adopted for children due to its ease of use.
• The review details FeNO's role in asthma diagnosis, prediction, and treatment monitoring in diverse pediatric populations.

Conclusions:

• Fractional exhaled nitric oxide (FeNO) is a practical and informative biomarker for pediatric asthma.
• FeNO testing addresses limitations of conventional methods, particularly in young children.
• FeNO aids in comprehensive asthma management, from diagnosis to treatment evaluation.