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Effect of Vitamin D on Anginal Episodes in Vitamin D Deficient Patients with Chronic Stable Angina on Medical
Suresh V Sagarad1, Neha Sukhani2, Basavaraj Machanur2
1Assistant Professor, Department of Cardiology, Rajiv Gandhi Super Speciality Hospital, Raichur Institute of Medical Sciences , Raichur, Karnataka, India .
Insights
Vitamin D supplementation significantly reduced angina episodes and nitrate use in deficient patients. Correcting vitamin D levels may offer cardiovascular benefits for angina patients.
Area of Science:
- Cardiology
- Endocrinology
- Nutritional Science
Background:
- Vitamin D deficiency is linked to cardiovascular diseases like hypertension and atherosclerosis.
- Short-term cardiovascular benefits of vitamin D supplementation remain under-reported.
Purpose of the Study:
- To investigate the impact of vitamin D supplementation on angina episodes in patients with chronic stable angina and vitamin D deficiency.
Main Methods:
- 40 patients were divided into two groups: one with low vitamin D and one with normal levels.
- The vitamin D deficient group received 60,000 IU weekly for 8 weeks.
- Anginal episodes and sub-lingual nitrate use were compared before and after supplementation.
Main Results:
- A significant reduction in anginal episodes (20%) and nitrate use (17.24%) was observed in the supplemented group.
- These benefits were independent of blood pressure, heart rate, and other medications.
- No significant changes were noted in the group with normal vitamin D levels.
Conclusions:
- Vitamin D deficiency assessment is crucial for cardiovascular patients.
- Vitamin D supplementation may provide additional cardiovascular benefits, including reduced angina.
Introduction:
Vitamin D deficiency has been found to contribute to various cardiac conditions, such as hypertension, coronary artery disease, stroke, and atherosclerosis. However, the clinical cardiovascular benefits after short term supplementation have not been reported.
Aim:
To study the beneficial effect of Vitamin D supplementation on angina episodes in Vitamin D deficient patients with chronic stable angina on medical management.
Materials And Methods:
A total of 40 patients were studied with group 1 (20 patients) with low Vitamin D levels and group 2 with normal Vitamin D levels. 60000 IU of Vitamin D supplementation was given every week for 8 weeks in group 1. Frequency of anginal episodes and use of sub-lingual nitrates were compared at base-line and after 8 weeks post supplementation.
Results:
Significant 20% (p <0.05) reduction in anginal episodes and 17.24% (p <0.05) reduction in use of sub-lingual nitrates was noted in group1 after Vitamin D supplementation. The benefits were independent of BP, heart rate and medications, thus, attributing to supplementation. No significant change was noted in group 2.
Conclusion:
Cardiovascular patients need to be evaluated for Vitamin D deficiency. Supplementation to correct Vitamin D levels may have additional cardiovascular benefits like reduction in angina episodes.
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