Protein Kinases and Parkinson's Disease
Syed Jafar Mehdi1, Hector Rosas-Hernandez2, Elvis Cuevas3
1Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. SJMehdi@uams.edu.
International Journal of Molecular Sciences
|September 23, 2016
Summary
Drug repurposing offers hope for Parkinson's disease treatment. Kinase inhibitors, used in cancer therapy, show promise for targeting Parkinson's disease pathways.
Area of Science:
- Neuroscience
- Pharmacology
- Drug Discovery
Background:
- Limited new drug candidates for neurological disorders like Parkinson's disease necessitate exploring drug repurposing.
- Approved drugs for other indications are being investigated for repositioning to treat Parkinson's disease.
- Kinase inhibitors are emerging as promising candidates due to the involvement of kinases in Parkinson's pathology.
Approach:
- This review examines kinase-dependent pathways implicated in Parkinson's disease.
- It evaluates the therapeutic potential of kinase inhibitors for Parkinson's disease treatment.
- Focus is on repurposing existing kinase inhibitors for neurological applications.
Key Points:
- Serine/threonine and tyrosine kinases play a role in Parkinson's disease pathobiology.
- Inhibitors targeting these kinases are potential therapeutic agents.
- Drug repurposing of kinase inhibitors is a viable strategy for Parkinson's disease.
Conclusions:
- Kinase inhibitors represent a promising avenue for Parkinson's disease drug development.
- Targeting kinase-dependent pathways could offer effective treatment strategies.
- Further research into kinase inhibitor repurposing is warranted for Parkinson's disease.
Related Concept Videos
01:15Parkinson's Disease: Overview
2.3K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.3K
01:24Parkinson's Disease: Treatment
1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
02:54Protein Kinases and Phosphatases
15.4K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.4K
02:54Protein Kinases and Phosphatases
4.6K
4.6K
01:37Neural Regulation
44.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.0K
01:02Phosphorylation
55.2K
The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
55.2K