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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Coagulation01:06

Coagulation

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Coagulation01:09

Coagulation

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
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Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

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Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
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Related Experiment Video

Updated: Mar 14, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

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[CONGENITAL DEFICIENCY OF COAGULATION FACTOR V].

M Kvezereli-Kopadze1, A Kvezereli-Kopadze1, M Chikovani1

  • 1Tbilisi State Medical University, G. Zhvania Pediatric Academic Clinic, Tbilisi, Georgia.

Georgian Medical News
|September 24, 2016
PubMed
Summary

A rare bleeding disorder, factor V deficiency, was diagnosed in a 5-year-old girl. Diagnosis involved family history, examination, and lab tests confirming low coagulation factor V levels.

Area of Science:

  • Hematology
  • Pediatric Medicine
  • Rare Diseases

Background:

  • Congenital coagulopathies are rare genetic disorders affecting blood clotting.
  • Factor V deficiency is an uncommon inherited bleeding disorder.
  • Early diagnosis and management are crucial for patients with bleeding disorders.

Observation:

  • A 5-year-old girl presented with a history of early-onset, persistent bleeding, including post-surgical tongue bleeding.
  • She had a positive family history of bleeding issues.
  • Physical examination revealed purpura, and laboratory tests showed significant hypocoagulation.

Findings:

  • Diagnostic workup, including coagulation factor analysis, confirmed a severe deficiency of coagulation factor V.
  • The patient's hypocoagulation showed only slight improvement with plasma transfusions, consistent with factor V deficiency.

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Related Experiment Videos

Last Updated: Mar 14, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

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Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
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Implications:

  • This case highlights the importance of thorough diagnostic evaluation for rare bleeding disorders in children.
  • Identifying factor V deficiency allows for targeted management and genetic counseling.
  • Understanding the clinical presentation aids in the early recognition of similar rare bleeding conditions.