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A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects
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Published on: August 14, 2013

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Hypertension and the eye

Lazaros Konstantinidis1, Yan Guex-Crosier

  • 1Jules-Gonin Eye Hospital, FAA, University of Lausanne, Switzerland.

Current Opinion in Ophthalmology
|September 24, 2016
PubMed

Insights

Hypertension`s effects on eye`s blood vessels, detected through advanced retinal imaging, can predict cardiovascular disease risk. These findings aid in managing hypertension and preventing end-organ damage.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Public Health

Background:

  • Hypertension is a leading global cause of cardiovascular disease and mortality.
  • Ocular microvasculature changes reflect systemic hypertensive risks.
  • The retina offers direct visualization of microvascular alterations.

Purpose of the Study:

  • To review recent advancements in detecting and understanding hypertension-related eye signs.
  • To highlight the significance of ocular findings in hypertension management.

Main Methods:

  • Review of current literature on retinal imaging and computer analysis.
  • Inclusion of recent epidemiological and genetic studies.
  • Focus on objective assessment of retinal vascular features.

Main Results:

  • Retinal microvascular changes can precede systemic disease progression.
  • Advanced imaging quantifies retinal vascular caliber, length-to-diameter ratio, and wall-to-lumen ratio.
  • Genetic studies link chromosomal loci to hypertensive retinopathy.

Conclusions:

  • Hypertensive retinopathy signs provide prognostic information on end-organ damage risk.
  • Ocular assessment can guide urgent systemic management and preventive therapies.
  • Improved retinal imaging and analysis tools will enhance hypertension diagnosis and management.
Abstract

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