The Large-Scale Organization of Object-Responsive Cortex Is Reflected in Resting-State Network Architecture
Talia Konkle1, Alfonso Caramazza1,2
1Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
Cerebral Cortex (New York, N.Y. : 1991)
|September 25, 2016
Summary
Long-range brain connections organize how we process visual objects, like animacy and size. This study reveals a nested network architecture supporting this large-scale cortical organization.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Systems Neuroscience
Background:
- Neural responses to visual objects exhibit large-scale spatial organization in the cortex.
- This organization is linked to object dimensions such as animacy and size.
- Differential connectivity is proposed as the primary driver of object-responsive cortex distinctions.
Purpose of the Study:
- To investigate the relationship between stimulus-evoked object organization and functional network architecture.
- To explore the role of resting-state functional connectivity in the large-scale organization of object-responsive cortex.
Main Methods:
- Utilized resting-state functional connectivity (rsFC) analysis.
- Employed a data-driven approach to identify whole-brain resting-state networks.
- Examined the routing of these networks through object-responsive cortical regions.
Main Results:
- Identified three distinct whole-brain resting-state networks that traverse object-responsive cortex.
- Observed that these networks naturally reflect the tripartite structure of stimulus-evoked object organization.
- Found high correlations between object-responsive regions at rest, indicating a nested network architecture.
Conclusions:
- Object-responsive cortex features a local, interconnected network and distinct subnetworks for long-range routing.
- Long-range connections are a significant driving force behind the large-scale spatial organization of object-responsive cortex.
- The findings support a model where network architecture shapes cortical responses to visual objects.
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