Related Experiment Video

Updated: Mar 14, 2026

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
10:25

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

10.2K

A neonate with a unique non-Down syndrome transient proliferative megakaryoblastic disease

Eline J M Bertrums1,2, Arjan Buijs3, Martine van Grotel1

  • 1Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Pediatric Blood & Cancer
|September 27, 2016
PubMed

Insights

Transient myeloproliferative disorder (TMD) is a rare leukemia in newborns. This study details a TMD case without trisomy 21, revealing novel genetic deletions that could aid diagnosis.

Area of Science:

  • Hematology
  • Pediatric Oncology
  • Genetics

Background:

  • Transient myeloproliferative disorder (TMD) is a leukemia primarily affecting newborns.
  • In Down syndrome, TMD is known as transient abnormal myelopoiesis (TAM).
  • Transient myeloproliferative disorder cases lacking trisomy 21 are uncommon, with few described genetic aberrations.

Observation:

  • A patient with transient myeloproliferative disorder (TMD) but without trisomy 21 or GATA1 mutation was analyzed.
  • Single-nucleotide polymorphism analysis was performed on the leukemic blasts.

Findings:

  • A novel, combined submicroscopic deletion was identified in the patient's leukemic blasts.
  • The deletion spans chromosomal regions 5q31.1-5q31.3 and 8q23.2q24.

Implications:

  • This finding expands the understanding of genetic alterations in TMD beyond trisomy 21.
  • The identified novel deletion may serve as a potential biomarker for specific TMD subtypes.
  • Further research into these genetic aberrations could improve diagnostic and clinical decision-making for TMD.
Keywords:
Down syndromeEXT1GATA1non-Down syndrometransient abnormal myelopoiesistransient leukemiatransient myeloproliferative diseasetransient myeloproliferative disordertrisomy 21

More Related Videos

Author Spotlight: Developing a Reproducible Method for Isolating Bone Marrow-Derived Macrophages from Neonatal Mice to Advance Early Life Immune Responses06:53

Author Spotlight: Developing a Reproducible Method for Isolating Bone Marrow-Derived Macrophages from Neonatal Mice to Advance Early Life Immune Responses

Published on: May 24, 2024

3.1K
Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry08:59

Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry

Published on: July 17, 2017

13.6K

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.2K
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
9.6K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.2K