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Atopic dermatitis--ichthyosis vulgaris--hyperlinear palms--an ultrastructural study.
M Fartasch1, T L Diepgen, O P Hornstein
1Department of Dermatology, University of Erlangen, FRG.
Dermatologica
|January 1, 1989
Summary
Autosomal dominant ichthyosis vulgaris (ADI) is often linked to atopic dermatitis (AD). However, this study found ADI is uncommon in AD patients, suggesting dry skin and hyperlinear palms are typically AD markers, not ADI signs.
Area of Science:
- Dermatology
- Genetics
- Histopathology
Background:
- Atopic dermatitis (AD) is frequently associated with autosomal dominant ichthyosis vulgaris (ADI).
- ADI diagnosis relies on ultrastructural evidence of abnormal keratohyalin (KH) granules.
- The prevalence of ADI in AD patients requires further investigation.
Purpose of the Study:
- To investigate the association between AD and ADI in patients with atopic dermatitis.
- To determine if clinical signs like dry skin and hyperlinear palms indicate ADI in AD patients.
Main Methods:
- Electron microscopy was used to examine skin biopsies from 49 AD patients.
- Clinical assessment for dry skin and hyperlinear palms was performed.
- Keratohyalin granule morphology was analyzed ultrastructurally.
Main Results:
- ADI was confirmed in only 2 (4%) of the 49 AD patients via electron microscopy.
- 17 patients exhibited hyperlinear palms, including the 2 with confirmed ADI.
- Dry skin and hyperlinear palms in AD patients are likely phenotypic markers of AD itself, not necessarily ADI.
Conclusions:
- The frequent association of ADI with AD may be overestimated.
- Hyperlinear palms and dry skin in AD patients are predominantly indicators of AD.
- An absent stratum granulosum in AD histology does not automatically imply ADI.