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Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
A CASE OF CONE DYSTROPHY ASSOCIATED WITH CHOROIDAL NEOVASCULARIZATION
Gokhan Gulkilik1, Sevil Karaman Erdur, Mustafa Eliacik
1Department of Ophthalmology, Istanbul Medipol University, Istanbul, Turkey.
This case report details choroidal neovascularization (CNV) in a patient with cone dystrophy (CD). A single ranibizumab injection effectively treated the condition, highlighting a potential therapeutic approach.
Area of Science:
- Ophthalmology
- Medical Genetics
Background:
- Cone dystrophy (CD) is an inherited retinal disorder primarily affecting cone photoreceptors.
- Choroidal neovascularization (CNV) is a known complication in various inherited retinal diseases.
Observation:
- A 20-year-old woman with CD presented with decreased vision and retinal hemorrhage.
- Fundus examination, OCT, and fluorescein angiography confirmed subfoveal CNV in one eye.
- Electroretinography results were consistent with cone dysfunction in both eyes.
Findings:
- A single intravitreal injection of ranibizumab successfully resolved macular edema and stabilized the CNV.
- The patient experienced vision stabilization over a 6-month follow-up period.
Implications:
- This case suggests a potential association between cone dystrophy and the development of CNV.
- Intravitreal ranibizumab may be an effective treatment for CNV in patients with cone dystrophy.
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