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Label-free Single Molecule Detection Using Microtoroid Optical Resonators
Published on: December 29, 2015
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Pulled microcapillary tube resonators with electrical readout for mass sensing applications.
Donghyuk Lee1, Joonhui Kim2, Nam-Joon Cho2
1School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, 08826, Korea.
Scientific Reports
|October 4, 2016
Summary
A novel microfabrication-free method creates hollow channel mass sensors using pulled glass capillaries. This cost-effective resonant mass sensing system accurately measures liquid density and droplet size distributions.
Area of Science:
- Materials Science
- Nanotechnology
- Sensor Technology
Background:
- Microfabrication techniques for hollow resonators are complex and costly.
- Development of accessible and efficient mass sensing platforms is crucial for various applications.
Purpose of the Study:
- To present a microfabrication-free approach for creating hollow channel mass sensors.
- To demonstrate the sensor's capability in measuring liquid density and droplet size distributions.
- To validate the performance of the proposed sensor system.
Main Methods:
- A glass capillary was pulled and suspended on a jig to create a pulled micro capillary tube resonator (PμTR).
- A piezo actuator excited the PμTR, and a quartz tuning fork (QTF) sensed its resonance frequency.
- Electrical and optical measurements validated the resonant spectra. Liquid samples were introduced to measure resonance frequency shifts with density changes.
Main Results:
- The PμTR demonstrated a density responsivity of -3,088 Hz-g⁻¹cm³, comparable to microfabricated hollow resonators.
- The system successfully measured the size distribution of oil droplets in water with a radius resolution of 31 nm.
- The resonant mass sensing system utilized off-the-shelf components with convenient electrical readout.
Conclusions:
- The microfabrication-free approach offers a simple and cost-effective method for fabricating hollow channel mass sensors.
- The developed sensor system is capable of precise liquid density and droplet size measurements.
- This technology provides a convenient and accessible resonant mass sensing solution.

