Related Experiment Video
Updated: Mar 14, 2026
08:39
Establishment of Deep Hypothermic Circulatory Arrest in Rats
Published on: December 16, 2022
2.9K
Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest
David R Busch1, Craig G Rusin2, Wanda Miller-Hance3
1Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Biomedical Optics Express
|October 5, 2016
Summary
Optical diffuse correlation spectroscopy (DCS) non-invasively monitors cerebral blood flow in neonates during heart surgery. This technology shows promise for guiding neuroprotective therapies by assessing microvascular flow.
Area of Science:
- Biomedical Engineering
- Neurosurgery
- Pediatric Cardiology
Background:
- Complex congenital heart defects impact pediatric survival rates.
- Neurological deficits are common in survivors, linked to cerebral ischemia.
- Current monitoring methods for cerebral blood flow during surgery are limited.
Purpose of the Study:
- To demonstrate optical diffuse correlation spectroscopy (DCS) for continuous, non-invasive monitoring of cerebral microvascular blood flow.
- To evaluate DCS performance during complex neonatal cardiac surgery.
- To explore DCS potential in guiding neuroprotective therapies.
Main Methods:
- Optical diffuse correlation spectroscopy (DCS) was employed for real-time monitoring.
- Measurements were taken during deep hypothermia, circulatory arrest, and rewarming.
- DCS data was compared with Doppler ultrasound flow measurements.
Main Results:
- DCS provided continuous and non-invasive assessment of cerebral microvascular blood flow.
- DCS measurements showed good agreement with Doppler ultrasound.
- This study is the first to demonstrate DCS in this clinical setting.
Conclusions:
- DCS is a viable tool for monitoring cerebral blood flow during neonatal cardiac surgery.
- Combined with NIRS, DCS could offer critical flow and metabolic biomarkers.
- This technology may enable clinicians to optimize neuroprotective strategies during surgery.
