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The Spinal Cord

The Spinal Cord

The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.

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Updated: Mar 14, 2026

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

Nanoparticle Technologies in the Spinal Cord.

Jonathan M Zuidema, Ryan J Gilbert, Donna J Osterhout

Cells, Tissues, Organs

|October 5, 2016

Summary

This summary is machine-generated.

Nanoparticles show promise for spinal cord injury (SCI) treatment by delivering therapeutic enzymes like chondroitinase ABC (chABC). This approach aids axonal regeneration and protects the enzyme, suggesting potential for future clinical applications in SCI.

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Published on: March 22, 2014

Area of Science:

Biomedical Engineering
Regenerative Medicine
Neuroscience

Background:

Spinal cord injury (SCI) presents significant challenges in neural repair and recovery.
Current therapeutic strategies for SCI are limited, necessitating novel approaches.
Nanoparticles offer versatile platforms for diagnostics and therapeutics in experimental SCI models.

Purpose of the Study:

To review nanoparticle applications in experimental spinal cord injury (SCI).
To evaluate the efficacy of nanoparticles in delivering chondroitinase ABC (chABC) for acute SCI in rats.
To assess the impact of nanoparticle-mediated chABC delivery on axonal regeneration and enzyme stability.

Main Methods:

Review of existing literature on nanoparticles for SCI.
In vivo studies using a rat model of acute SCI.
Local delivery of chABC via nanoparticles post-injury.
Assessment of axonal regeneration and enzyme degradation.

Main Results:

Nanoparticles demonstrated successful local delivery of chABC in an acute rat SCI model.
chABC-releasing nanoparticles promoted significant axonal regeneration.
Nanoparticles protected chABC from rapid degradation, enhancing its therapeutic potential.
Various nanoparticle types are being explored for SCI diagnostics and therapeutics.

Conclusions:

Nanoparticles are effective carriers for therapeutic agents like chABC in experimental SCI.
This delivery system promotes axonal regeneration and enzyme stability, crucial for SCI recovery.
Nanoparticles hold significant potential for future clinical translation in treating spinal cord injuries.