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Penicillin Use in Meningococcal Disease Management: Active Bacterial Core Surveillance Sites, 2009

Amy E Blain1, Sema Mandal1, Henry Wu1

  • 1Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases , Centers for Disease Control and Prevention , Atlanta, Georgia.

Open Forum Infectious Diseases
|October 6, 2016
PubMed

Insights

Penicillin was infrequently used for meningococcal disease in 2009 due to inconsistent susceptibility testing and the availability of cephalosporins. Current practices may influence future treatment guidelines for this bacterial infection.

Area of Science:

  • * Infectious Diseases
  • * Microbiology
  • * Public Health Surveillance

Background:

  • * Meningococcal disease remains a significant public health concern.
  • * Treatment of bacterial meningitis requires timely and effective antimicrobial therapy.
  • * Historical treatment practices influence current clinical guidelines.

Purpose of the Study:

  • * To analyze the utilization of penicillin for meningococcal disease in 2009.
  • * To identify factors influencing antibiotic choice in managing meningococcal infections.
  • * To provide insights for updating future treatment protocols.

Main Methods:

  • * Analysis of data from Active Bacterial Core surveillance sites in 2009.
  • * Review of antimicrobial susceptibility testing availability and usage patterns.
  • * Assessment of the role of third-generation cephalosporins in treatment.

Main Results:

  • * Penicillin was not a commonly prescribed antibiotic for meningococcal disease in 2009.
  • * Inconsistent antimicrobial susceptibility testing availability was noted.
  • * Third-generation cephalosporins were frequently utilized due to ease of administration and availability.

Conclusions:

  • * Current treatment practices for meningococcal disease may not prioritize penicillin.
  • * The reliance on cephalosporins highlights the need for accessible susceptibility data.
  • * Findings can inform the development of evidence-based management guidelines for meningococcal disease.
Keywords:
Neisseria meningitidisantimicrobial resistancemeningitismeningococcal disease

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