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Spatial Memory in the Progeny of Rats Subjected to Different Types of Experimental Preeclampsia
V N Perfilova1, G A Zhakupova2, L I Lashchenova1
1Volgograd State Medical University, Volgograd, Russia.
Abstract:
Spatial memory was studied in 2-month-old offspring of rats subjected to different types of experimental preeclampsia (replacement of drinking water with 1.8% NaCl from day 1 to 21 of gestation or intraperitoneal administration of non-selective NO-synthase inhibitor L-NAME to pregnant rats in a daily dose of 25 mg/kg for 7 days on gestation days 14-20). Spatial memory was evaluated in an elevated 8-arm radial maze. Both types of experimental preeclampsia impaired spatial (long-term and short-term) memory and can be used in the development of drugs correcting negative effects of this pregnancy complication on memory.
