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Embedding magnetic nanoparticles into coordination polymers to mimic zinc ion transporters for targeted tumor therapy

Enguo Ju1, Zhaowei Chen2, Wei Li1

  • 1Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing, 100039, China.

Chemical Communications (Cambridge, England)
|October 7, 2016
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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