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Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
Published on: August 23, 2016
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Zika virus epidemic: an update.
Gregory Valentine1, Lucila Marquez2, Mohan Pammi3
1a Department of Pediatrics , One Baylor Plaza , Houston , TX , USA.
Expert Review of Anti-Infective Therapy
|October 8, 2016
Summary
Zika virus (ZIKV) is a growing global health concern, causing microcephaly and other developmental issues in newborns. This review covers ZIKV epidemiology, diagnostics, and prevention, recommending expanded screening for pregnant women.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Zika Virus (ZIKV) has rapidly spread, becoming a pandemic in the Americas.
- ZIKV is definitively linked to microcephaly, ophthalmic anomalies, and other congenital issues.
- The virus's rapid transmission and severe sequelae have heightened medical concern.
Purpose of the Study:
- To consolidate current knowledge on ZIKV epidemiology.
- To review diagnostic methods and screening recommendations.
- To discuss preventive strategies, including vaccine development.
Main Methods:
- Literature review of ZIKV epidemiology.
- Analysis of diagnostic testing modalities.
- Examination of CDC screening guidelines and preventive measures.
Main Results:
- ZIKV infection poses significant risks to fetal development, including microcephaly.
- Unknowns persist regarding long-term effects and lineage-specific virulence.
- Current screening may miss cases, particularly when sexual transmission is involved.
Conclusions:
- Expanded ZIKV screening for pregnant women with fetal anomalies is recommended, even without known travel history.
- Further research is needed on ZIKV's long-term impacts and genomic variations.
- Enhanced vigilance and testing are crucial for managing the ZIKV public health emergency.
