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Isolation and Characterization of Microvesicles from Peripheral Blood
06:03

Isolation and Characterization of Microvesicles from Peripheral Blood

Published on: January 6, 2017

23.9K

Microvesicles in Autoimmune Diseases

M-L Liu1, K J Williams2, V P Werth1

  • 1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Corporal Michael J. Crescenz VA Medical Center (Philadelphia), Philadelphia, PA, United States.

Advances in Clinical Chemistry
|October 9, 2016
PubMed

Insights

Cellular microvesicles, released during apoptosis, can accelerate autoimmune responses. This review examines their role in the pathogenesis and complications of autoimmune diseases.

Area of Science:

  • Cell Biology
  • Immunology
  • Pathogenesis

Background:

  • Cells release membrane microvesicles (microparticles) during apoptosis or activation.
  • These microvesicles contain proteins, lipids, and nucleic acids, acting in intercellular communication.
  • Apoptosis is linked to autoimmune disease development.

Purpose of the Study:

  • To review studies on the role of microvesicles in autoimmune disease pathogenesis.
  • To explore how microvesicles contribute to autoimmune responses.

Main Methods:

  • Literature review of studies implicating microvesicles in autoimmune diseases.
  • Analysis of microvesicle composition and function in intercellular communication.

Main Results:

  • Abnormally persistent microvesicles, especially apoptotic ones, can accelerate autoimmune responses.
  • Microvesicles contribute to both local and systemic autoimmune reactions.

Conclusions:

  • Microvesicles play a significant role in the pathogenesis of autoimmune diseases.
  • Further research into microvesicles is crucial for understanding and treating autoimmune disorders.
Keywords:
AngiogenesisAutoimmune inflammationAutoimmunityEndothelial dysfunctionMicroparticleMicrovesicleThrombosisVascular inflammationmiRNAssiRNAs

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