Time-lapse embryo imaging and morphokinetic profiling: Towards a general characterisation of embryogenesis

Area of Science:

• Reproductive Biology
• Biotechnology
• Animal Science

Background:

• In vitro fertilisation (IVF) is a key assisted reproductive technology for humans and animals.
• Optimizing embryo selection is crucial for successful implantation and reducing multiple gestations.
• Current methods rely on standard microscopic observation of embryo morphology.

Purpose of the Study:

• To review the application of time-lapse technology in embryogenesis characterisation.
• To assess the role of time-lapse technology in improving embryo selection.
• To discuss the potential of time-lapse technology in human and livestock embryology.

Main Methods:

• Review of current literature on time-lapse imaging in embryology.
• Analysis of time-lapse technology's non-invasive observation capabilities.
• Discussion of commercial time-lapse devices and their clinical applications.

Main Results:

• Time-lapse technology provides continuous, uninterrupted embryo observation from fertilisation to transfer.
• It offers a non-invasive alternative to standard microscopic assessment.
• Ongoing research aims to refine its use for improved embryological outcomes.

Conclusions:

• Time-lapse technology is valuable for characterising embryogenesis and enhancing embryo selection.
• Its potential extends to identifying aneuploidy in human embryos.
• The technology can improve embryological procedures in agriculturally important species like pigs and cows.