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Published on: March 14, 2025
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Clinicopathologic evaluation of malignancy adjacent to dental implants
Ilana Kaplan1, Itai Zeevi2, Haim Tal3
1Rabin Medical Center, Petah-Tikva, Israel; School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
|October 11, 2016
Summary
Peri-implant malignancy, a rare oral cancer, can mimic peri-implantitis, delaying diagnosis. Early suspicion and histopathology are key for accurate diagnosis and treatment, especially in high-risk patients.
Area of Science:
- Oral oncology
- Dental implantology
- Pathology
Background:
- Peri-implantitis is a common complication of dental implants.
- Malignancies can occur around dental implants, mimicking peri-implantitis.
- Distinguishing between peri-implantitis and peri-implant malignancy is critical for patient outcomes.
Purpose of the Study:
- To present a case series of peri-implant malignancies.
- To review existing literature on peri-implant malignancies.
- To discuss the diagnostic challenges and implications of peri-implant malignancies that resemble peri-implantitis.
Main Methods:
- Retrospective analysis of cases diagnosed between 2000 and 2016.
- Literature review of English-language studies on peri-implant malignancies.
Main Results:
- Seven cases of peri-implant malignancy were identified, representing 1.5% of oral malignancies.
- Common types included squamous cell carcinoma and basal cell carcinoma.
- Delayed diagnosis occurred in six cases due to misinterpretation as peri-implantitis; risk factors included prior malignancy, potentially malignant conditions, and smoking.
Conclusions:
- Peri-implant malignancy is a rare but significant entity.
- Clinical presentation can mimic peri-implantitis, leading to diagnostic delays.
- Increased suspicion for malignancy is warranted in non-responsive lesions, particularly in patients with risk factors; histopathology is essential for definitive diagnosis.

