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Related Concept Videos

Protein Complex Assembly02:41

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Polypeptide self-assemblies: nanostructures and bioapplications.

Chunhua Cai1, Jiaping Lin1, Yingqing Lu1

  • 1Shanghai Key Laboratory of Advanced Polymeric Materials, State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. jlin@ecust.edu.cn.

Chemical Society Reviews
|October 11, 2016
PubMed
Summary
This summary is machine-generated.

Polypeptide copolymers self-assemble into complex nanostructures for drug delivery and biomimetic mineralization. This review highlights advances in polypeptide self-assemblies, focusing on structure-property relationships for novel bioapplications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Polypeptide copolymers exhibit self-assembly into various aggregate structures.
  • Morphology is tunable via molecular design, assembly conditions, and additives like polymers or nanoparticles.
  • Polypeptide self-assemblies are promising for therapeutic delivery and biomimetic mineralization.

Purpose of the Study:

  • To provide an overview of recent advances in polypeptide self-assemblies.
  • To highlight strategies for constructing complex and functional polypeptide assemblies for bioapplications.
  • To emphasize the structure-property relationships of polypeptide aggregates.

Main Methods:

  • Review of recent scientific literature on polypeptide self-assemblies.
  • Analysis of strategies for controlling nanostructure formation.
  • Discussion of structure-property relationships and bioapplication potential.

Main Results:

  • Recent advances enable the construction of increasingly complex polypeptide assemblies.
  • Novel functionalities are being developed for diverse bioapplications.
  • A strong correlation exists between the structure and properties of polypeptide aggregates.

Conclusions:

  • Polypeptide self-assemblies offer versatile platforms for advanced bioapplications.
  • Further research is needed to overcome challenges in complexity and functionality.
  • Understanding structure-property relationships is key to unlocking full potential.