Related Experiment Video
Updated: Mar 13, 2026
Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
Published on: November 29, 2019
Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis
M Alba Mañé-Martínez1, Bob Olsson2, Laura Bau3
1Joan XXIII University Hospital, Universitat Rovira i Virgili, Tarragona, Spain; Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Abstract:
In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, α-sAPP, β-sAPP, and Aβ38, Aβ40, Aβ42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients.
