Related Experiment Video

Updated: Mar 13, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.8K

Involvement of microRNAs in HER2 signaling and trastuzumab treatment

Ling Mao1,2, Ai-Jun Sun2, Jian-Zhong Wu1

  • 1Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|October 14, 2016
PubMed

Insights

MicroRNAs (miRNAs) play a crucial role in HER2 signaling and trastuzumab treatment for cancers like breast and gastric. This review explores miRNAs targeting HER2 and mechanisms of trastuzumab resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • HER2 protein is a prognostic marker in breast, gastric, and ovarian cancers.
  • Trastuzumab, an anti-HER2 antibody, improves outcomes for HER2-positive cancers but resistance is a challenge.
  • Understanding HER2 signaling and resistance mechanisms is key to developing new strategies.

Approach:

  • This review summarizes microRNAs (miRNAs) that target HER2.
  • It details miRNA activity in biological processes and their role in HER2 signaling.
  • The review highlights miRNAs regulating trastuzumab resistance and associated molecular mechanisms.

Key Points:

  • miRNAs are small non-coding RNAs involved in HER2 signaling and trastuzumab response.
  • Specific miRNAs target HER2, influencing cancer progression.
  • miRNAs are implicated in both intrinsic and acquired resistance to trastuzumab.

Conclusions:

  • miRNAs offer potential strategies to overcome trastuzumab resistance.
  • miRNA signatures associated with HER2 and trastuzumab activity are discussed.
  • Potential miRNA biomarkers for trastuzumab sensitivity are explored.
Keywords:
HER2MicroRNATrastuzumab

More Related Videos

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.7K
Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

7.1K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.5K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K